Reproductive Safety Study with Mangifera indica in Mice
نویسندگان
چکیده
Mango fruit (Mangifera indica) is rich of phytoestrogens, polyphenols, calcium, iron and potassium which play an important role in bone and dental growth and development. The aim of this study was to determine the effect of M. indica on embryos in pregnant mice. Twenty four pregnant mice were equally divided into 3 groups of those receiving aquous extract of the mango fruit, its alcoholic extract and the control group receiving just distilled water. Animals were sacrificed at 19 day of pregnancy and embryos were removed and th fixed in 10% formalin for histological studies. No abnormality and teratogenic effects were noticed in bone, cartilage, liver, spleen, kidney, digestive tract and spinal cord tissues. M. indica can be administered safely during pregnancy while improves bone and dental tissues growth and development.
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